Here is a link to the Phase 1 clinical study I wrote about yesterday, featuring Cylene Pharmaceuticals’ CX-4945:
The study is currently recruiting participants. Here are some highlights:
This Phase 1 study of oral CX-4945 is designed to test the safety, tolerability, and highest safe dose level of this CK2 inhibitor in patients with relapsed or refractory multiple myeloma.
Ages Eligible for Study: 18 Years and older
Genders Eligible for Study: Both
Accepts Healthy Volunteers: No
•Males or females at least 18 years of age
•Confirmed relapsed or refractory multiple myeloma after at least two prior lines of therapy.
•Karnofsky Performance Status at least 60%
•Adequate liver and renal function and hematology laboratory values
•Female patients of child-bearing potential must have a negative pregnancy test.
•Signed informed consent.
•Treatment with systemic cancer therapy within 21 days before screening.
•Major surgery within 4 weeks or minor surgery within 2 weeks of the start of study drug.
•Grade 3 sensory neuropathy or motor neuropathy with pain
•Concurrent severe or uncontrolled medical disease.
•Active systemic fungal, bacterial, and/or viral infection.
•Difficulty with swallowing, or an active malabsorption syndrome.
•Gastrointestinal diseases including Crohn’s disease or hemorrhagic coloproctitis.
•History of gastric or small bowel surgery.
•Pregnant or nursing females.
United States, Oregon
Oregon Health Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Farnoush Abar, MD email@example.com
Springfield, Oregon, United States, 97477
Contact: Jeanne Schaffer, RN firstname.lastname@example.org
United States, South Carolina
Greenville, South Carolina, United States, 29605
Contact: Jan Kueber, RN email@example.com
United States, Virginia
Norfolk, Virginia, United States, 23502
Contact: Gabrielle Geho, RN Gabrielle.Geho@usoncology.com
This is one of dozens of clinical trials which are currently seeking participants with multiple myeloma. This one is more experimental than most. There are certainly no guarantees of success. But if you are running out of options, you might consider getting involved.
Feel good and keep smiling! Pat