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Monthly Archives: October 2010

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30 10, 2010

Experimental Heat Shock Inhibitor Works Great Against Multiple Myeloma–In A Test Tube

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Thomas, a good e-mail friend from Germany, forwarded me information about a new, possibly revolutionary anti-myeloma Heat Shock Inhibitor this week.  Here are some links about this new therapy,  PU-H71:http://meeting.ascopubs.org/cgi/content/abstract/28/15_suppl/8141http://onlinelibrary.wiley.com/doi/10.1002/jlcr.1689/pdfhttp://www.mskcc.org/mskcc/html/60263.cfmhttp://insciences.org/article.php?article_id=7680The last three links were provided by my editor at The Myeloma Beacon, Julie Shilane.  Thanks for the updates, Thomas and Julie!  From Germany to Princeton, New

30 10, 2010

New Study Confirms Less Is More When Using The Bisphosphonate, Aredia, In Multiple Myeloma Patients

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Lots of excitement and questions swirling around bisphosphonates lately.  Aredia is the tried and true, less expensive, more conservative option.  Zometa is much stronger than Aredia and requires a far shorter infusion time.  Both drugs can cause osteonecrosis of the jaw (OMJ).  A brand new alternative, Prolia should also be available soon.  There are other

29 10, 2010

Unexpected Tour Of The Institute For Myeloma & Bone Cancer Research: Interview With Dr. James Berenson- Part Four

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Dr. Berenson and I talked about a number of things while we toured his facility.  His disdain for using stem cell transplants (SCT) as a standard of care in newly diagnosed patients.  The growing trend of using maintenance therapy following these transplants, even though there is no clear cut evidence maintenance therapy extends median life

28 10, 2010

Unexpected Tour Of The Institute For Myeloma & Bone Cancer Research: Interview With Dr. James Berenson- Part Three

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There is no question stem cell transplants (SCTs) help many patients for a number of years. But the procedure is not without risk—and some patients get very little benefit in the end.As with most things in life, timing is everything! How and when it is best to undergo a SCT is one of the most

27 10, 2010

Unexpected Tour Of The Institute For Myeloma & Bone Cancer Research: Interview With Dr. James Berenson- Part Two

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As I shared with you yesterday, I had an unexpected chance to speak with Dr. James Berenson at the Institute for Myeloma & Bone Cancer Research in Los Angeles earlier this week. Allow me to share more about my visit: After leaving Dr. Li (Willy), the Institute’s Principal Scientist and returning to Dr. Berenson’s office,

26 10, 2010

Unexpected Tour Of The Institute For Myeloma & Bone Cancer Research: Interview With Dr. James Berenson- Part One

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I apologize for the delay in getting today’s article online. I’m flying back to Tampa from LA, and the much touted and over-hyped on-board Wi-Fi on my Delta flight wouldn’t connect with my laptop browser. Translation: No internet connection for almost six hours. I was out in Los Angeles doing some freelance media work, While

24 10, 2010

The Myeloma Beacon Reports Details About FDA’s Bisphosphonate Alert

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There has been a lot of interest and concern about the recent FDA warning about bone strengthening drugs like Fosamax, Actonel, Boniva, Reclast and Boniva.The Myeloma Beacon ran a reassuring article about the warnings for multiple myeloma patients taking the IV bisphosphonates Aredia and Zometa:New FDA Warning About Bisphosphonates Does Not Apply To Multiple Myeloma

22 10, 2010

An Inside Look At How Top Myeloma Experts Feel About Induction Therapy & Use Of SCT In Newly Diagnosed Multiple Myeloma Patients

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HemOnctoday posted an excellent review of the new, state of the art anti-myeloma induction therapy using a combination of Revlimid, Velcade and dexamethasone (RVD) last week.  The article features a number of well known myeloma experts and is quite long. Toward the end of the article, yesterday's topic about whether to continue using stem cell transplant

21 10, 2010

Which Is Most Effective: Novel Therapy Agents Or Bone Marrow (Stem Cell) Transplants?

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Regular reader and fellow cancer blogger David Everson asked I share this article with you:Which is more effective for newly diagnosed multiple myeloma- novel therapies or bone marrow transplant?The single greatest debate in the conventional treatment of newly diagnosed multiple myeloma today is whether to treat with "novel" therapies or to have an autologus bone

20 10, 2010

Be Careful: Radiation Cancer Risks Swirl All Around Us

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After reading my series comparing the risks of diagnostic radiation exposure, Maureen Denard took things one step farther, writing an article about more general, everyday radiation risks.  She has kindly given me permission to share her post with you today:10 Surprising Places You’re Being Overexposed to RadiationRadiation. The word alone scares us, but we’re exposed to it on

19 10, 2010

Link To Hopeful Webinar About Living With Multiple Myeloma For A Long, Long Time

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Here is a link to a helpful, well produced webinar, featuring Nick Tiller and 16+ year multiple myeloma survivor Lt. Frank Cronin, about living with multiple myeloma and the efforts of the MMRF to cure this disease.Worth a look, especially for newly diagnosed patients and/or those who are "freaked out" multiple myeloma median life expectancy

18 10, 2010

Hernando County, Florida Multiple Myeloma Support Group Meeting Wednesday

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The new Hernando County, Florida Multiple Myeloma Support Group meets the 3rd Wednesday of each month at the Spring Hill Enrichment Center.  That means the October meeting is this Wednesday, October 20th at 6 PM.The Spring Hill Enrichment Center is located on the campus of Oak Hill Hospital, 11375 Cortex Blvd (Hwy 50)  Brooksville, FL 34613.  The

17 10, 2010

Some Good News About Vorinostat: Oncologists Can Use It "Off Label" In Multiple Myeloma Patients

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I would like to take this opportunity to once again thank Dr. Eric Rubin, Vice President of Merck Oncology, for taking the time to update us on vorinostat's projected timeline.You may have noticed quite a bit of hedging and "drug company speak" toward the end of our interview.  I want to point out that Dr. Rubin wasn't intentionally

16 10, 2010

Part Two Of A Two Part Interview With Merck Oncology’s Vice President, Dr. Eric Rubin, About New Anti-Multiple Myeloma Drug, Vorinostat

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Here is the second part of my two part interview with Dr. Eric Rubin, Vice President of Merck Oncology, makers of vorinostat--trade name Zolinza:My understanding is, like many anti-myeloma agents, Zolinza is most effective when combined with other novel therapy agents. Which combinations show the most promise thus far? Why do you think that is?All

15 10, 2010

Part One Of A Two Part Interview With Merck Oncology’s Vice President, Dr. Eric Rubin, About New Anti-Multiple Myeloma Drug, Vorinostat

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I have written a lot about two developmental, anti-myeloma drugs here recently, carfilzomib and pomalidomide.  But there are a number of other new, experimental drugs on the horizon.One of these, vorinostat, looks expecially promising.  Vorinostat is being developed by Merck Oncology.  Vorinostat doesn't do much to fight multiple myeloma on it's own.  But early combination

14 10, 2010

More About Using Killer Cells To Stop Multiple Myeloma

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Yesterday I wrote an article about UAMS researcher's attempts to harness the power of "killer cells."  Here are links to several other articles about killer cell research I have written this past year:  Swiss Study Attempting To Kill Multiple Myeloma Using "Killer Cells!"http://www.helpwithcancer.org/2010/09/researchers-hope-our-bodys-rnai.htmlhttp://multiplemyelomablog.blogspot.com/2010/09/reader-question-what-is-mdx-1097.htmlDifferent approaches but same basic idea.  Hope something works! Feel good and keep smiling!  Pat