Here is another interesting research finding about bone strength/health from Australia’s Rheumatology Update:
High uric acid promotes bone health
Higher serum uric acid levels in
older men are strongly associated
with increased bone mineral
density (BMD) and markers of
calcium homoeostasis and bone
resorption, landmark Australian
research has shown.
A study led by Professor Markus
Seibel at the ANZAC Research
Institute in Sydney examined 1,705
community-dwelling men aged
70 or more who participated in
the Concord Health and Ageing
in Men Project (CHAMP).
After adjusting for possible
confounders, BMD at all sites
was significantly higher among
those with uric acid levels
above the group median.
Uric acid levels were also
positively associated with serum
calcium, parathyroid hormone
D levels. They were negatively
associated with urinary NTX-1,
a marker of bone resorption.
Above-median uric acid levels
were also associated with a lower
prevalence of osteoporosis at the
femoral neck and lumbar spine,
and a lower prevalence of vertebral
and non-vertebral fractures.
The researchers said their
study was the first to examine
links between uric acid
levels and bone health.
Uric acid had traditionally
been viewed as a waste product
which caused gouty arthritis
and kidney stones, and also
led to endothelial damage and
increased cardiovascular risk.
However, it was also thought to
provide an evolutionary benefit by
helping to maintain blood pressure
under low-salt conditions.
Emerging evidence suggested
that uric acid was a
powerful antioxidant that could
help protect against conditions
including Alzheimer’s disease,
and possibly osteoporosis.
The cross-sectional nature of the
study did not allow any causeand-
effect mechanisms to be
explored, but there were several
other plausible explanations for
uric acid’s apparent benefits,
including a direct effect on bone
resorption, the researchers said.
Evidence is growing that using more than one novel therapy agent at the same time helps delay disease (myeloma) progression. Research studies like the one above makes me wonder if multiple myeloma patients might soon be using a combination approach for bone health as well, combining calcium and vitamin D and bisphosphonates with additional uric acid type supplements.
Feel good and keep smiling! Pat