I have received a number of calls and e-mails recently from patients who’s multiple myeloma has become active again while using Revlimid, Velcade, or both. Here is a short, hopeful response I found addressing this on the Multiple Myeloma Research Foundation (MMRF) Website:
Treatment Options for Relapsed or Refractory Patients Failing Revlimid and Velcade:
Q&A with Dr. Keith Stewart, Mayo Clinic, Scottsdale, Arizona
What are my current options if I fail Revlimid® (lenalidomide) and Velcade® (bortezomib)?
Fortunately, there are many existing therapies available for the treatment of relapsed and/or refractory myeloma. Conventional chemotherapy drugs that may be effective include Cytoxan® (cyclophosphamide), melphalan, and anthracyclines such as doxorubicin or Doxil® (doxorubicin HCL liposome injection). Thalomid® (thalidomide) may still be an option if patients have not received it previously. These drugs may be used in various combinations that may even include trying Velcade or Revlimid again.
High dose chemotherapy followed by autologous stem cell transplantation may also be appropriate for some patients.
In addition, clinical trials with new drugs in development are an option as well.
Tomorrow: Dr. Stewart’s review of clinical trials which may be available to these patients.
Feel good and keep smiling! Pat