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Dr. Berenson’s post-transplant therapy advice

Home/About Pat, Therapy, Tips/Dr. Berenson’s post-transplant therapy advice

Dr. Berenson’s post-transplant therapy advice

Yesterday I shared impressive, in-depth therapy analysis of my case by Dr. Robert Orlowski, at M.D. Anderson in Houston, Texas.

Today, let’s hear what Dr. James Berenson, founder of the Institute for Myeloma and Bone Cancer Research in Los Angeles, has to say.

I interviewed Dr. Berenson in his offices just outside of Beverly Hills late last October.

I really could see this sign, standing in his office lobby.  I thought that was pretty impressive!

Here are links to a series of articles I wrote following the interview:

Interview:  Part One

Interview:  Part Two

Interview:  Part Three

Interview:  Part Four

Can’t get enough of Dr. Berenson?  Simply type his name into the black query bar in the upper right corner of the page.  Not the grey bar (that’s a Google search), but the longer bar just above it.

Here is Dr. Berenson’s response to my plea for help and advice after I learned that my stem cell tranplant may not have worked:

I am sorry to hear the news.

Too bad as I was lecturing in Tampa on Monday nd Tuesday and even went to the Monday night football game.

In terms of your disease, I am very concerned about the rapid return of disease following the transplant.

In general, I would recommend our DVD-R regimen that we just presented on for this type of rapid relapse.  The problem is that Doxil is now unavailable for any new patients because the company has messed up their production of the drug.

I would consider using Vitamin C at 1 g orally at dinnertime on days 1, 2, 3, and 4 with Cytoxan in place of Doxil at a dose of 2.2 mg/kg orally days 1, 2, 3, and 4 at bedtime.

You can find our DVD-R regimen results from the ASCO meeting proceedings.  The dose and schedule of DEX IV, Velcade and Revlimid are in the abstract and should not be changed when you replace Doxil with Vitamin C and Cytoxan.  You will notice that our cycle length is every 4 not 3 weeks and our doses of both Revlimid (10 mg) and Velcade (1.0 mg/m2) are lower.  Importantly the DEX is 40 mg but IV not orally and given on Velcade days.  


James R. Berenson, MD

Institute for Myeloma & Bone Cancer Research

Thank you, Dr. Berenson!  Lots of useful, specific information here.

Note Dr. Berenson is on-board with trying RVD again–he is simply suggesting “tweaking” the consolidation cocktail, upping the number of therapy agents from three to five…  Sorry I asked!

On the dark side, note what he had to say about my M-protein levels RISING after my SCT:

In terms of your disease, I am very concerned about the rapid return of disease following the transplant.

OUCH!  So those of you in the back who feel I have been a bit melodramatic this past week, sit back down!

As with Dr. Orlowski’s recommendations yesterday, I think I will wait to discuss Dr. Berenson’s therapy suggestions later when things settle down.

Tomorrow:  Reader comments

Later this weekend:  Suggestions to help you get second opinions–like these consults–by phone or email.

Feel good and keep smiling!  Pat