Please Subscribe to get a daily link to Pat's blog via email


Your privacy is important to us. We will never spam you and keep your personal data secure.

JQ1 discovery worth a second look…

Home/Inspirational, Research/JQ1 discovery worth a second look…

JQ1 discovery worth a second look…

I had a feeling that I might be “stirring things up a bit” when I wrote yesterday’s article,

New multiple myeloma research video is “smokin’ hot”… But is there any real fire there?

But the response has been overwhelming. 

The thing many of you don’t realize, is if three comments show-up following a particular blog post, I receive up to a dozen emails directly.  This is understandable.  Some people simply aren’t comfortable commenting publicly.  Others don’t want to “embarrass me” if they don’t agree with something I’ve written.  Sometimes, readers can’t figure out how to post a comment–although this new format seems to be a bit more reader friendly.

But most often, something I write will lead to a personal medical question from a patient or caregiver, and they would like me help.   I love that!

Actually, I love it all!  Yes, I wish more of you would comment publicly, even if we don’t always agree.

But I don’t care how you chose to interact; in the comment section, by email or even by phone.  Hearing from you always makes my day!

Back to yesterday’s article.  I took the position that if you look past the bells and whistles, and an impressive YouTube video presentation, Dr. James Bradner’s JQ1 isn’t any different than a large number of pre-clinical trials that cross my desk each month.

I wasn’t “dissing” Dr. Bradner’s work.  I was simply trying to make the point that there are lots of reasons for all of us in the multiple myeloma community to be hopeful–and JQ1 is just one of many of those reasons.

I apologize if some of you felt “let down” by what was perceived to be my “cynical approach” to Dr. Bradner’s work.

But here’s the thing.  I broke this story and wrote an upbeat, positive article about JQ1 two months ago:

Researchers Hope Shutting-Down MYC May Be Key To Defeating Myeloma

Click-on the link above.  What’s the first thing you notice?  Dr. Bradner’s charismatic smile!

What’s the first thing I notice?  The long list of hard working clinicians which have contributed to the JQ1 research effort!

I was so impressed at the time, I made sure to include the long list of names in my post. Dr. Bradner was chosen to be the face of JQ1.  And it’s working!  I received still another link back to his TED/YouTube video from another multiple myeloma caregiver this morning.  The guy’s a superstar!  He even changed his name for the video from “Dr. James Bradner” to “Jay Bradner.”  The PR consultants must have thought that made him more likeable.  Really?

Oops!  My cynical side is sneaking out again.  I don’t want these important/impressive research results to get lost amidst the slicked-up glitz and glamor…

So instead of relegating the article to my other, less oft read research blog,, I felt that JQ1 was important enough to share here, with you directly.

I’m not being defensive.  I’m just thrilled that so many of you are paying attention! 

Want hope?  Check-out at least once a week–especially with the big ASH meetings coming up in December.  There will be lots of exciting research news breaking constantly from now through the end of the year.

The Dana-Farber JQ1 research group is to be commended for making their exciting data freely available to the myeloma research community.  They should also get “props” for doing such an excellent job promoting the project.

Maybe this approach will help speed-up the clinical process.  As I wrote in September:

“Yes, like many others, I’m guessing that researchers may be a decade away from developing a patient friendly application for this new anti-myeloma/cancer technology. “

Here’s hoping that 1) JQ1 turns-out to have a practical application which can help myeloma patients and 2) We don’t have to wait decades for this important research to work it’s way through the system.

Lives are depending on it.

Feel good and keep smiling!  Pat