One of our readers sent me a link to this excellent Mayo Clinic video about amyloidosis last month and I forgot to post it.
Its one of the best I’ve seen on the subject. Plus it focuses on a three drug combination used by multiple myeloma patients, Revlimid, Velcade and dexamethasone (RVD).
Give it a look:
Next, yesterday I wrote a post on HWC (Help With Cancer.org) about a fascinating and successful individualized medicine project. Apparently researcher have been able to grow and nurture a patient’s own tumor cells in their lab, allowing them to expose these “tumors” to different chemotherapy options before trying them in their patient.
The implications are obvious and hopeful, don’t you think? Here’s the link to my post:
Exciting new way to individualize cancer therapy
Have a great Sunday, everyone! Feel good and keep smiling! Pat
October 1st, 2012 at 5:31 pm
Thank you for the update.
I have found information about activity of doxycycline on all kinds of amyloid deposites. ( it can improve disease symptoms).
Doxycycline is old antibiotic from tetracycline group. http://en.wikipedia.org/wiki/Doxycycline
I am very encouraged that BU unrolling clinical trial without any support from any pharmaceutical company.
http://clinicaltrials.gov/ct2/show/NCT01677286?term=doxycycline+%2B+amyloid&rank=1
bellow few links related to doxycylnine
EU granted ophran drug to doxycycline for dialysis induced amyloidosis:
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/orphans/2012/04/human_orphan_001036.jsp&mid=WC0b01ac058001d12b
doxycycline in vivo (mouse with AL amyloidosis )
http://www.ncbi.nlm.nih.gov/pubmed/21998211
doxycycline in vivo (mouse with TTR amyloidosis )
Clinical trial on TTR amyloidosis
http://clinicaltrials.gov/ct2/show/NCT01171859
doxycycline in dialysis related amyloidosis
http://www.jbc.org/content/286/3/e99905
I hope that this information may be useful for some of your readers.
Have a nice day.
Igor.
October 1st, 2012 at 11:30 pm
Fascinating, Igor. Much appreciated!