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Hopeful research uses a patient’s own T cells to battle myeloma

Posted on April 06 2013 by Pat Killingsworth | 973 views

Not much news to report from the 14th annual Myeloma Workshop in Kyoto, Japan.  I know there are a large number of poster study results being displayed, along with oral presentations, too.  But I’m not there and I don’t believe anyone is covering the event from the Myeloma Beacon, either.  Regardless, I would like to take a different tact and examine important ongoing research at Dartmouth College.

If you have been doing any reading at all about the latest and most promising cancer therapies lately, you have undoubtedly read about “T-cells.”  My science background is sketchy at best, so sometimes I have trouble following the more technical aspects of some study results.  That’s why I found this article to be so fascinating.  It is written for you and me!  I recommend you read, Improving immunity against multiple myeloma, By Lauren Ware.

Apparently, T cells with certain markers are more effective than other lymphocytes in combating myeloma.  Researchers identified the marker(s), manipulated cells from patient’s blood and then re-infused-it along with an immune-boosting molecule.  One of the unusual things about this therapy is it would be applied at the time a patient undergoes an auto (using their own cells) stem cell transplant.  What a great idea!

Dr. MeehanResults look promising, but it is still not known how much these modified, super T cells might help.  From what I read, sounds like Dartmouth researchers are on the right track.

Dartmouth’s BMT program director, Dr. Kenneth Meehan, closed that article by saying, “This is really an example of bench to bedside, back to bench and to bedside again.”

Ingenuous, exciting and hopeful!  I’m convinced that therapies like this will some day allow me and my fellow myeloma patients to live longer–a lot longer.

Feel good and keep smiling!  Pat

 

5 Comments For This Post

  1. Terry L Says:

    Great news! Perhaps, some day these souped up T cells could do their thing without having to undergo a SCT.

  2. Pat Killingsworth Says:

    Even better!

  3. suzierosee Says:

    I agree Terry!

    Hopefully, they will be able to do induction therapy, then test for MRD, and add the Tcells to clean up!!

    A far better regimen for patients!

  4. JustinS Says:

    Pat,

    My understanding is that this has been going on at Penn Medicine (it was one of the experimental options for my dad). Is this a different technique than what is done at Penn and do you know how many patients have undergone the treatment?

    Thanks.

  5. Pat Killingsworth Says:

    Sorry Justin, I don’t. Like most, original study was very small; less than 20 I believe.

2 Trackbacks For This Post

  1. Myeloma according to twitter | Multiple Myeloma Blog Says:

    […] Several of the top myeloma experts recently supported my work on twitter. Dr. Robert Orlowski, featured yesterday’s post in his The Multiple Myeloma Daily newsletter:  Hopeful research uses a patient’s own T cells to battle myeloma. […]

  2. Myeloma according to twitter | Cure Talk Says:

    […] Several of the top myeloma experts recently supported my work on twitter. Dr. Robert Orlowski, featured yesterday’s post in his The Multiple Myeloma Daily newsletter:  Hopeful research uses a patient’s own T cells to battle myeloma. […]

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