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Science fiction? NO! It’s myeloma therapy!

Posted on July 03 2014 by Pat Killingsworth | 882 views

Can myeloma research get any more complicated?  Check out this article, courtesy our friends at Dana-Farber:

Scientists Engineer Nanoparticles to Prevent Bone Cancer, Strengthen Bones

June 30, 2014

A research collaboration between Dana-Farber Cancer Institute and Brigham and Women’s Hospital (BWH) and has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression.

The study is published the week of June 30, 2014 in Proceedings of the National Academy of Sciences.

“Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression,” said Archana Swami, PhD, BWH Laboratory of Nanomedicine and Biomaterials, co-lead study author. “We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression.”

“There are limited treatment options for bone cancers,” added Michaela Reagan, PhD, of Dana-Farber’s Center for Hematologic Oncology, co-lead study author. “Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone with minimal off-target effects.”

The scientists developed stealth nanoparticles made of a combination of clinically validated biodegradable polymers and alendronate, a clinically validated therapeutic agent, which belongs to the bisphosphonate class of drugs. Bisphosphonates bind to calcium. The largest store of calcium in the human body is in bones, so bisphosphonates accumulate in high concentration in bones.

By decorating the surface of the nanoparticles with alendronate, the nanoparticles could home to bone tissue to deliver drugs that are encapsulated within the nanoparticles and kill tumor cells, as well as stimulate healthy bone tissue growth. Furthermore, bisphosphonates are commonly utilized during the treatment course of cancers with bone metastasis, and thus alendronate plays a dual role in the context of these targeted nanoparticles.

The scientists tested their drug-toting nanoparticles in mice with multiple myeloma, a type of bone cancer. The mice were first pre-treated with nanoparticles loaded with the anti-cancer drug, bortezomib, before being injected with myeloma cells. The treatment resulted in slower myeloma growth and prolonged survival. Moreover, the researchers also observed that bortezomib, as a pre-treatment regimen, changed the make-up of bone, enhancing its strength and volume.

“These findings suggest that bone-targeted nanoparticle anti-cancer therapies offers a novel way to deliver a concentrated amount of drug in a controlled and target-specific manner to prevent tumor progression in multiple myeloma,” said Omid Farokhzad, MD, director of the BWH Laboratory of Nanomedicine and Biomaterials, co-senior study author. “This approach may prove useful in treatment of incidence of bone metastasis, common in 60 to 80 percent of cancer patients and for treatment of early stages of multiple myeloma.”

irene-ghobrialAdded Irene Ghobrial, MD, of Dana-Farber’s Center for Hematologic Oncology, co-senior study author: “This study provides the proof-of-concept that targeting the bone marrow niche can prevent or delay bone metastasis. This work will pave the way for the development of innovative clinical trials in patients with myeloma to prevent progression from early precursor stages or in patients with breast, prostate or lung cancer who are at high-risk to develop bone metastasis.”

This research was supported by the United States Department of Defense (W81XWH-13-1-0390), National Institutes of Health (CA151884, CA133799), Movember-PCF Challenge Award, David Koch-Prostate Cancer Foundation Award in Nanotherapeutics, and a Friends of the Farber Grant.

Nanomedicine?  Nanoparticles?  Nanotherapeutics?  Remind me, who’s arguing against teaching more math and science in our classrooms?  Amazing!

As former teachers, Pattie and I often talk about ways to improve basic education in here, especially in states like Florida.  The first step: stop hiring elementary and middle school teachers that don’t have math and science training!  Want to cure cancer?  Nurturing our children is important, but I’m all for helping produce more nanoparticle-type thinkers!

Feel good and keep smiling!  Pat

6 Comments For This Post

  1. suzierose Says:

    Hi Pat,

    This is unclear:
    “The scientists tested their drug-toting nanoparticles in mice with multiple myeloma, a type of bone cancer. The mice were first pre-treated with nanoparticles loaded with the anti-cancer drug, bortezomib, before being injected with myeloma cells. The treatment resulted in slower myeloma growth and prolonged survival. Moreover, the researchers also observed that bortezomib, as a pre-treatment regimen, changed the make-up of bone, enhancing its strength and volume.”

    How can we have pre-therapy? We do not get therapy until AFTER we have myeloma. These mice were injected with myeloma AFTER getting the bortezomib infused nano particles…

    Maybe I am missing something but I do not see how this sequence plays out in real life where we have myeloma before the treatment.

  2. Pat Killingsworth Says:

    Specifics aside, it is both encouraging and antagonizing for me to follow theoretical laboratory studies. So often what works in the lab doesn’t work in human patients. Honestly, I publish this type of thing because so many patients, caregivers and family members find it hopeful. Pie-in-the-sky, win the lottery type of hopeful. Most aren’t interested in details, only the idea that there may be something more to help them someday…

  3. Brian Helstien Says:

    Sounds like something that might be valuable with MGUS, but as suzierose points out, unless it is part of a vaccine-huh?

  4. Pat Killingsworth Says:

    I have no idea, Brian. I figure, “Throw enough at the wall and something’s going to stick!” One day, one of these “far out” therapy ideas is going to be the one that helps break myeloma therapy out of the IMiD and PI rut!

  5. blustein2 Says:

    That statement about hiring elementary and middle school teachers with a math or science background is totally unrealistic. Those are not the skills needed to teach elementary school. In additiom, people with those type of backgrounds will not be content simply teaching elementary school. My final argument is that you would have to pay them alot more than you are paying them now.

  6. Pat Killingsworth Says:

    I disagree. Not with the skill set part. I get that. But why not strive for both? Another example of how our country is always settling. Why not hire better teachers and pay them more? Some states are already doing it. You’ve been in Florida too long!

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