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proteasome inhibitors

Home/Tag:proteasome inhibitors
9 09, 2015

Ixazomib granted priority review by FDA

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The myeloma world doesn't stop spinning just because I'm waiting for test results. With so much excitement surrounding the immunotherapies elotuzumab and daratumumab, another promising new drug, ixazomib (MLN9708), is often overlooked. That's a mistake, especially for patients that have successfully responded to Velcade and/or Kyprolis. This morning the FDA granted the oral proteasome inhibitor

21 11, 2013

Staggering amount of myeloma related data to be revealed at this year’s ASH (Part Two)

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I promised more information about the upcoming American Society of Hematology (ASH) meetings in New Orleans; specifically data from promising clinical trials and laboratory studies that will be presented there.  Last week I ran these posts: Staggering amount of myeloma related data to be revealed at this year’s ASH (Part One)   Innovative genetic diagnostics

26 10, 2013

Mayo Clinic demystifies proteasome inhibitors

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I just read an incredibly detailed and helpful review of FDA approved--and experimental--proteasome inhibitors . Three up-and-coming myeloma specialists at Mayo Clinic, Vinay Gupta, Wilson Gonsalves and Shaji Kumar.  Did you know that there are four second generation PIs in the research pipeline? Oprozomib, ixazomib, marizomib and delanzomib are all "currently being investigated in clinical

25 09, 2012

Is it “all about the money?” Depends how you spin it…

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In case you missed it, the U.S. Food and Drug Administration has set a date for an advisory committee meeting to review the company’s application for approval of pomalidomide:  November 8th of this year. The agency is expected to make a decision about pomalidomide’s (New trade name, Actimid) application sometime early in February, 2013. Pomalidomide

9 09, 2012

News for myeloma patients about their bones

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Here are a pair of bone-related news stories that broke this past week: Myeloma Drugs May Help Build Bone By John Gever, Senior Editor, MedPage Today Published: September 07, 2012 Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner Two proteasome inhibitors developed for