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Tag Archive | "thalidomide"

curcumin

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Exciting curcumin research revisited

Posted on 05 September 2013 by Pat Killingsworth

An impressive website, NaturalNews.com, just published an article about turmeric’s  (curcumin) ability to destroy myeloma cells when combined with thalidomide.  I first wrote about this project back in July:

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A rabbi, stock broker and Celgene exec walk into a bar…

Posted on 17 July 2013 by Pat Killingsworth

Before I get started this morning, I wanted to share some sage advice that I received from one of my regular readers after they learned I was struggling with my father’s life nearing the end:

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molocule

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Could synthesizing and combining anti-myeloma drugs make them more effective?

Posted on 07 July 2013 by Pat Killingsworth

This is complicated stuff.  But apparently a group of scientists have successfully synthesized thalidomide and curcumin.  Taking things a step farther, researchers Kai Liu, Datong Zhang, Jeremy Chojnacki, Yuhong Du, Haian Fu, Steven Grant and Shijun Zhang have also been able to combine thalidomide and curcumin together, forming a compound that is exceptionally lethal to myeloma cells.  Here’s the group’s abstract: 

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Pomalyst

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What took so long? Pomalidomide time-line raises questions–I have answers (Part Three)

Posted on 17 April 2013 by Pat Killingsworth

I stuck with the original heading for the third installment of my three part investigative expose’.  But today’s post could have been titled, “Different shades of grey.”   Pomalidomide’s development was shaped by a convoluted system that does a poor job balancing patient need with investor returns.

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What took so long? Pomalidomide time-line raises questions–I have answers (Part Two)

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What took so long? Pomalidomide time-line raises questions–I have answers (Part Two)

Posted on 16 April 2013 by Pat Killingsworth

Before I get started, did you happen to see the MMRF’s Kathy Giusti interviewed in the trendy tech magazine, Fast Company?  Interesting approach.  Simply click-on the headline link below to access the interview:

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The crazy world of “myeloma research speak”

Posted on 09 April 2012 by Pat Killingsworth

Most of you probably know that I have been working on several new books about multiple myeloma. 

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Dr. Phillippe Moreau

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Data presented at the IMF’s Journalist Workshop takes me on an emotional roller-coaster ride

Posted on 15 December 2011 by Pat Killingsworth

Yesterday I set the stage for today’s report about research data which was featured at the International Myeloma Foundation’s Journalist Workshop Monday night.

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Hate Taking Steroids? Maybe New VDT Anti-Multiple Myeloma Therapy Is Right For You!

Posted on 06 September 2011 by Pat Killingsworth

Do you hate taking dexamethasone or prednisone?  This new therapy combination of Velcade, pegylated liposomal doxorubicin (D), and thalidomide (T), may provide an an alternative option.  Here is an abstract from a Phase 2 trial featuring the VDT combination:

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History Of Anti-Myeloma Drugs, Thalidomide & Revlimid

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History Of Anti-Myeloma Drugs, Thalidomide & Revlimid

Posted on 24 May 2011 by Pat Killingsworth

I saved the link to this interesting article about the history of thalidomide, I found a few months back on a mainstream site called SLATE.  Here are some selected excerpts from the article, along with a link to access the full text:

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FDA Revlimid/Thalomid Investigation Update

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FDA Revlimid/Thalomid Investigation Update

Posted on 12 April 2011 by Pat Killingsworth

The Myeloma Beacon just broke the story about how the FDA is investigating Revlimid and Thalomid, based on research data showing a possible secondary cancer risk following long term, post transplant use.

Here is an independent look at the pending investigation by Internal Medical News.  I have highlighted key points I feel are important:

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Excellent Article About Geraldine Ferraro’s Legacy And Ongoing Battle To Help Control Cost Of Cancer Meds…

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Excellent Article About Geraldine Ferraro’s Legacy And Ongoing Battle To Help Control Cost Of Cancer Meds…

Posted on 31 March 2011 by Pat Killingsworth

Read this detailed recap/tribute to Geraldine Ferraro by Ann Law for Bizmology.com:

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Thalomid Or Velcade Both Work At Least 50% Of The Time In Patients Facing First Relapse

Posted on 09 March 2011 by Pat Killingsworth

According to a new Czech study, posted earlier this month on Pub Med.gov, it doesn’t matter whether you pick thalidomide (Thalomid) or bortezomib (Velcade) for treatment following first relapse.  Apparently both work about one half of the time.

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A Bit Of Positive News During An Otherwise Slow Myeloma-Related News Cycle

Posted on 03 March 2011 by Pat Killingsworth

Multiple myeloma news runs in cycles and streaks.  The calendar revolves around the two largest U.S. hematology and oncology conferences:  The American Society of Clinical Oncologists (ASCO) meetings in June, and the American Society of Hematology (ASH) meetings in December.

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What Happens After My Stem Cell Transplant? To Use Maintenance Or Not Use Maintenance – That Is The Question!

Posted on 24 February 2011 by Pat Killingsworth

Yesterday I shared how–after almost four years–I have decided to go ahead with a stem cell transplant.

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Insightful Newspaper Article About Pomalidomide/Biaxin/Dex Clinical Study In New York City

Posted on 26 January 2011 by Pat Killingsworth

Here is an interesting article I found in the Cornell Daily Sun this morning.  Interesting because it is combines basics with a very insightful look at a promising clinical trial featuring pomalidomide:

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10 Year Multiple Myeloma Survivor Shares His Story

Posted on 16 January 2011 by Pat Killingsworth

Fellow blogger, caregiver and regular reader, Lori Puente, forwarded me a link to this article about a 10 year multiple myeloma survivor a few weeks ago.  I saved it to pass along when I got a chance:

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Reader Shares His Multiple Myeloma Story

Posted on 12 November 2010 by Pat Killingsworth

Late last month I received this e-mail comment from fellow patient Jack Searight, in response to my four part series of articles following my visit with multiple myeloma specialist Dr. James Berenson in Los Angeles.   Jack apparently had trouble getting Blogger to accept his comment.  From my experience, Jack’s difficulties are not unusual.  I think this is one reason more readers don’t comment and participate regularly.

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Hope For Multiple Myeloma Patients When Revlimid & Velcade Stop Working

Posted on 08 November 2010 by Pat Killingsworth

I have received a number of calls and e-mails recently from patients who’s multiple myeloma has become active again while using Revlimid, Velcade, or both.  Here is a short, hopeful response I found addressing this on the Multiple Myeloma Research Foundation (MMRF) Website:
Treatment Options for Relapsed or Refractory Patients Failing Revlimid and Velcade:

Q&A with Dr. Keith Stewart, Mayo Clinic, Scottsdale, Arizona
What are my current options if I fail Revlimid® (lenalidomide) and Velcade® (bortezomib)?
Fortunately, there are many existing therapies available for the treatment of relapsed and/or refractory myeloma. Conventional chemotherapy drugs that may be effective include Cytoxan® (cyclophosphamide), melphalan, and anthracyclines such as doxorubicin or Doxil® (doxorubicin HCL liposome injection). Thalomid® (thalidomide) may still be an option if patients have not received it previously. These drugs may be used in various combinations that may even include trying Velcade or Revlimid again.

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Evidence Is Mounting Supporting Maintenance Therapy

Posted on 31 October 2010 by Pat Killingsworth

I know this isn’t what most multiple myeloma patients want to hear, but the evidence is growing that it is better to stay on some type of maintenance therapy indefinitely.  This applies to those who undergo a stem cell transplant and those who don’t. 

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Comprehensive Study Completed On Chemotherapy Induced Peripheral Neuropathy (CIPN), Including Thalidomide/Velcade

Posted on 01 October 2010 by Pat Killingsworth

A fellow multiple myeloma patient forwarded me this excellent, comprehensive review of peripheral neuropathy he found on a site called FAQS.org.  Here are some of the highlights:

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